Bioactive Small Molecules
Cayman Chemical ANTIBODY lY-283 5mg
A PRMT5 inhibitor (IC50 = 22 nM); selective for PRMT5 over a panel of 32 methyltransferases at 1 μM; reduces symmetric demethylation of SmBB' in MCF-7 cells (IC50 = 25 nM); reduces proliferation of various cancer cell lines (IC50s = 3-30 nM); inhibits tumor growth in an A375 mouse xenograft model at 20 mg/kg; disrupts alternative splicing events in, and inhibits proliferation and self-renewal of, patient-derived glioblastoma stem cells; increases survival in an orthotopic PCX mouse model
eMolecules 210344-98-2 | Ambeed | Z-IETD-FMK | 1mg | 552756202 | A772438 | MFCD03490491 | 654.689 | C30H43FN4O11
Ambeed | 3-Acetyl-26-dichloropyridine | 100mg | 521400504 | A125388 | 412018-50-9 | MFCD11847148 | 190.020 | C7H5Cl2NO
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Medchemexpress LLC KRCA-0008 | 1472795-20-2 | MFCD28133395 | >95.0% | 609.12 g·mol^-1 | C30H37ClN8O4 | 10MG
KRCA-0008 is a selective dual inhibitor of anaplastic lymphoma kinase (ALK) and activated Cdc42-associated kinase 1 (Ack1) used in cancer research. Reported biochemical IC50 values are 12 nM for ALK and 4 nM for Ack1. The compound is supplied as a powder for research use only.
- Selective dual ALK and Ack1 inhibitor
- Reported IC50: ALK 12 nM; Ack1 4 nM
- Molecular formula C30H37ClN8O4; molecular weight 609.12 g·mol^-1
- Supplied as a powder for laboratory use
- Recommended storage: powder at -20°C (long term) or 4°C (short term); in solution at -80°C
- Suitable for biochemical and cancer biology research (research use only)
Enzo Life Sciences BAY 61-3606. hydrochloride (25mg). CAS: 648903-57-5
Cell permeable, potent, ATP-competitive and reversible inhibitor of spleen tyrosine kinase (Syk) (IC50=10nM). Highly selective if compared to other kinases; shows no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src up to concentrations of 4.7µM. Anti-inflammatory and orally active. Exhibits good in vivo efficacy in the treatment of various allergy and asthma conditions in rat models. Alternative name: 2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide . HCl. Purity: ≥98% (HPLC(UV)). Solubility: Soluble in water (30mg/ml), DMSO (2mg/ml) or methanol (1mg/ml). Long Term Storage: -20°C.
Cayman Chemical CCZ01048trIfluoroacetAT sa 5mg
A synthetic peptide; has been conjugated to radioligands for use in PET imaging of tumors expressing MC1R and for tissue distribution studies in vivo
Cayman Chemical ANTIBODY BZAD-01 5mg
An antagonist of NR2B subunit-containing NMDA receptors (Ki = 72 nM); selective for NR2B subunit-containing NMDA receptors over those containing NR2A subunits (IC50s = 47 and >10,000 nM, respectively); reduces carrageenan-induced hyperalgesia in rats (ED50 = 5.5 mg/kg); reduces dopaminergic neuron loss in the rat substantia nigra pars compacta and improves measures of ipsilateral curling, ipsilateral head positioning, and beam walking in a rat model of 6-OHDA-induced Parkinson’s disease at 10 mg/kg
Medchemexpress LLC Insulin receptor (1142-1153), pTyr1150 | 134177-41-6 | 99.4% | 1702.71 | 5 MG
Insulin receptor (1142-1153), pTyr1150 is a biologically active peptide. It is used as an insulin receptor tyrosine kinase substrate.
- Biologically active peptide
- Used as an insulin receptor tyrosine kinase substrate
Medchemexpress LLC TAT (47-57), FAM-labeled acetate | 1918.13 (free base) | 5 MG
TAT (47-57), FAM-labeled acetate is a FAM-labeled cell-penetrating peptide (CPP) with potential for use in intracellular drug delivery studies. It is soluble in H2O at concentrations of 50 mg/mL or higher.
- FAM-labeled cell penetrating peptide
- Potential for use in intracellular drug delivery studies
- Soluble in H2O
- Used in peptide and drug delivery research
- Fluorescent-labeled peptide
Medchemexpress LLC RIP2 Kinase Inhibitor 3 | 1398053-50-3 | 99.8% | 388.48 | 100 MG
RIP2 Kinase Inhibitor 3 is a highly potent and selective inhibitor of receptor interacting protein-2 (RIP2) Kinase with an IC50 of 1 nM. This product is for research use only and not intended for sale to patients.
- Highly potent and selective inhibitor of RIP2 kinase
- IC50 of 1 nM (RIP2)
TARGETMOL CHEMICALS INC ML-098 25MG
Also available in 1 mg 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50 77.6 nM). purity: 99%
Cayman Chemical 4-methyl-N-Methylbuphedron 5mg
A para-methyl analog of buphedrone with an aminomethyl addition; intended for research and forensic applications
Medchemexpress LLC B7-H2/ICOSLG Human 20ug | 20ug
B7-H2/ICOSLG Protein a ligand for T-cell receptor ICOS critically costimulates T-cell proliferation and cytokine secretion It induces B-cell proliferation and supports plasma cell differentiation playing a key role in local tissue responses to inflammation B7-H2/ICOSLG also modulates the secondary immune response by co-stimulating memory T-cell function In molecular interactions it has been observed to interact with CTLA4 in vitro B7-H2/ICOSLG Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived B7-H2/ICOSLG protein expressed by HEK293 with C-Avi C-His labeled tag
Cayman Chemical ANTIBODY LEE011 25mg
A selective cyclin D1/CDK4 and cyclin D3/CDK6 inhibitor (nm IC50) that inhibits retinoblastoma protein phosphorylation, which prevents CDK-mediated G1-S phase transition, arresting the cell cycle in the G1 phase, suppressing DNA synthesis, and inhibiting cancer cell growth; reduces proliferation of several human neuroblastoma-derived cell lines (mean IC50 = 306 nM)
Cayman Chemical ANTIBODY XLR12 1mg
A trifluorobutyl analog of XLR11; intended for forensic and research applications
Medchemexpress LLC Macupatide acetate | 99.95% | 4984.60 | 10 MG
Macupatide acetate is a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist designed to improve insulin secretion responses and enhance insulin sensitivity. It is suitable for research related to type 2 diabetes.
- Greater improvement in insulin sensitivity demonstrated in vitro
- Enhances insulin sensitivity
- Suitable for type 2 diabetes research