Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,046 – 6,060 of 60,541 results

6,046

Cayman Chemical PD 166866, Purity: ≥98%, CAS: 192705-79-6, 5 mg

A potent inhibitor of FGFR1 (IC50 = 52.4 nM; Ki = 45.2 nM); selective for FGFR1 over PDGFR, EGFR, C-SRC, MEK, PKC, insulin receptor tyrosine kinase, and CDK4 (IC50s = >50 μM); inhibits FGFR1 autophosphorylation in NIH3T3 and L6 cells (IC50s = 10.8 and 3.1 nM, respectively); inhibits phosphorylation of MAPK (IC50 = 4.3 and 7.9 nM for the 44- and 42-kDa MAPK isoforms, respectively); reduces FGF- but not EGF- or PDGF-stimulated growth of L6 cells and inhibits microvessel outgrowth from human placental arteries in vitro; inhibits growth of NSCLC cell lines a dose-dependent manner; reduces migration of VL-8 cells at a concentration of 10 μM

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6,047

Apexbio Technology LLC MDL-800, 25mg CAS# 2275619-53-7

MDL-800 is a selective activator of SIRT6 which increases SIRT6 deacetylation activity by up to 22-fold, causing a decrease in H3K9Ac and H3K56Ac levels in human HCC cell, leads to cell cycle arrest and inhibition of cell proliferation. It also suppresses xenograft tumor growth HCC cells in immunocompromised mice. Other sizes are also available. Please inqury us for quote.

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6,048

Enzo Life Sciences Tranilast (10mg). CAS: 53902-12-8

Anti-inflammatory and anti-angiogenic agent. Inhibits VEGF-induced angiogenesis in vivo . Inhibits proliferation and tube formation of human endothelial cells in vitro. Also inhibits smooth muscle cell proliferation and prevents post-angiplasty retsenosis.Synthetic compound with structural similarity to the tryptophan (Trp) catabolites kynurenines. Tranilast ameliorates the disease severity in animal models of multiple sclerosis, in part, by inducing T cell tolerance. Trp degradation is an important mechanism in the maintenance of T cell tolerance in a variety of disease models and is mediated by the rate limiting enzyme indoleamine 2,3-dioxygenase (IDO). Alternative name: N-(3',4'-Dimethoxycinnamoyl)anthranilic acid, 3,4-DAA. Purity: ≥95% (HPLC). Appearance: Off-white to yellow solid. Solubility: Soluble in DMSO. Long Term Storage: -20°C.

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6,049

Apexbio Technology LLC ABT-737, 50mg. Cas: 852808-04-9 MFCD: MFCD12756212. Bcl-2 inhibitor

ABT-737 is a novel and potent inhibitor of B-cell lymphoma 2 (BCL-2) family proteins, which are critical for cell survival and overexpressed in many tumor cells, with high affinity towards BCL-XL, BCL-2, and BCL-w but no affinity towards less homologous proteins, such as BCL-B, MCL-1, and A1. Other sizes are available. Please inqury us for quote.

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6,050

Apexbio Technology LLC Trifluoperazine 2HCl, 100mg Cas# 440-17-5

Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. Other sizes are available. Please inqury us for quote.

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6,051

Cayman Chemical 1,2-Dioleoyl-sn-glycero-3-PS (sodium salt), Purity: ≥95%, CAS: 90693-88-2, 5 mg

A phospholipid; SapC-1,2-DOPS nanovesicles are cytotoxic to SK-MEL-28 cells in vitro and decrease tumor volume in a squamous cell carcinoma mouse xenograft model; has been used in the formation of unilamellar vesicles to study the effect of curvature on membrane structure and in the formation of supported lipid bilayers to study the effects of various support materials on lipid redistribution between membrane leaflets

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6,052

TARGETMOL CHEMICALS INC RRX-001 5MG

Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. RRx-001 is a potent inhibitor ofglucose 6-phosphate dehydrogenase(G6PD) and with potent antimalarial activitypurity: 98%

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6,053

Apexbio Technology LLC Roxatidine Acetate HCl, 5g Cas# 93793-83-0

Roxatidine Acetate HCl is a specific and competitive histamin H2 receptor antagonist. Other sizes are available. Please inqury us for quote.

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6,054

Cayman Chemical Sparstolonin B, Purity: ≥95%, CAS: 1259330-61-4, 5 mg

An isocoumarin with diverse biological activities; inhibits increases in TNF-α, IL-6, and IL-1β levels induced by LPS, Pam3CSK4, or FSL-1 but not poly(I:C) or ODN1668 in primary mouse macrophages at 100 µM; reduces HIV-1 p24 antigen levels in the culture supernatant of human PBMCs infected with HIV-1 at 1-10 µM; induces apoptosis, cell cycle arrest at the G2/M phase, and production of ROS in SH-SY5Y cells at 10 µM; protects mice from lethal endotoxin shock at 3 and 9 mg/kg

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6,055

Cayman Chemical Hydroxy Bosentan, Purity: ≥98%, CAS: 253688-60-7, 5 mg

A metabolite of bosentan; produced by CYP3A4 and CYP2C9

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6,056

Cayman Chemical Illudin M, Purity: ≥85%, CAS: 1146-04-9, 5 mg

A DNA alkylating agent from the fungus O. illudens; cytotoxic to HL-60 cells at 6-100 nM

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6,057

Medchemexpress LLC PRO20 | 99.2% | 2341.82 | 25 MG

PRO20 is a specific and competitive (pro)renin receptor (PRR) antagonist. It inhibits Prorenin-induced calcium influx with an IC50 value of 81 nmol/L. PRO20 works by blocking the binding of prorenin to the PRR, which in turn inhibits the activation of the renin-angiotensin system (RAS) and reduces the production of angiotensin II (Ang II). It is considered promising for research into antihypertensive agents.

Specific and competitive (pro)renin receptor (PRR) antagonist
Inhibits prorenin-induced calcium influx
Reduces the production of angiotensin II (Ang II)
Promising for research into antihypertensive agents

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6,058

Medchemexpress LLC ATI-2341 TFA | 98.1% | 2256.82 (free base) | 5 MG

ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4). This compound activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization.

Acts as a biased ligand, favoring Gαi activation over Gα13
Potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs)
Potent and efficacious mobilizer of hematopoietic stem and progenitor cells (HSPCs)

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6,059

Medchemexpress LLC Benzenepropanoic acid, a-oxo- | 156-06-9 | 99.9% | 164.16 | 1 ML

Phenylpyruvic acid is a precursor of the antifungal compound phenyllactic acid. It can improve the antifungal activity of eight lactic acid bacterial strains when added to a defined growth medium. Phenylpyruvic acid demonstrates improved inhibitory activity against fungal bread contaminants such as Aspergillus niger and Penicillium roqueforti. It affects enzyme activity of the pentose phosphate pathway involved in the oxidative phase in rat brain homogenates and can reduce glucose-6-phosphate dehydrogenase activity.

Precursor of antifungal compound phenyllactic acid.
Improves antifungal activity of lactic acid bacterial strains.
Demonstrates improved inhibitory activity against fungal bread contaminants (Aspergillus niger and Penicillium roqueforti).
Affects enzyme activity of the pentose phosphate pathway in rat brain homogenates.
Reduces glucose-6-phosphate dehydrogenase activity.

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6,060

Cayman Chemical MK-886, Purity: ≥98%, CAS: 118414-82-7, 10 mg

A potent FLAP antagonist that prevents 5-LO activation in vivo; inhibits LT biosynthesis in leukocytes with an IC50 value of 2.5 nM

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Medchemexpress LLC PRO20 | 99.2% | 2341.82 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC ATI-2341 TFA | 98.1% | 2256.82 (free base) | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Benzenepropanoic acid, a-oxo- | 156-06-9 | 99.9% | 164.16 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC PRO20 | 99.2% | 2341.82 | 25 MG

Medchemexpress LLC ATI-2341 TFA | 98.1% | 2256.82 (free base) | 5 MG

Medchemexpress LLC Benzenepropanoic acid, a-oxo- | 156-06-9 | 99.9% | 164.16 | 1 ML